Serena Williams Drops a Bombshell: Why She Thought Weight Loss Shots Were Cheating – Until Oprah Changed Everything” In a jaw-dropping confession, tennis icon Serena Williams opens up to Oprah about why she once rejected weight loss shots—calling them a “shortcut” and “cheating.” But after years of struggle, failed diets, and brutal workouts, her perspective took a shocking turn. What changed her mind? The answer will surprise you.

“Serena Williams Drops a Bombshell: Why She Thought Weight Loss Shots Were Cheating – Until Oprah Changed Everything” In a jaw-dropping confession, tennis icon Serena Williams opens up to Oprah about why she once rejected weight loss shots—calling them a “shortcut” and “cheating.” But after years of struggle, failed diets, and brutal workouts, her perspective took a shocking turn. What changed her mind? The answer will surprise you.

Serena Williams Tells Oprah Why She Thought Weight Loss Shots Was Cheating

US former tennis player Serena Williams attends the 2025 TIME100 gala at The Jazz at Lincoln Center in New York, April 24, 2025. TIME’s annual TIME100 Next list recognizes 100 individuals who are defining the next generation of leadership Artists, Phenoms, Leaders, Advocates and Innovators poised to make the climb and in doing so, make history. (Photo by ANGELA WEISS / AFP) (Photo by ANGELA WEISS/AFP via Getty Images)

Serena Williams has changed her mind about taking shots to lose weight.

Speaking with Oprah Winfrey, Williams explained that she was “absolutely” skeptical of taking GLP-1 medication.

Yes, because it’s like ‘the skinny shot’ and ‘it’s a shortcut,’” Serena on The Oprah Podcast. “So, for a long time, I didn’t do it, and I didn’t want to do it, and I thought, ‘I’m not going to take the shortcut. I’m going to work harder.’”

After giving birth to her daughters, Olympia, 8, and Adira, 2, Williams said she “tried everything” without success.

I tried every diet, I’ve tried every workout,” she continued. “I’ve tried walking for hours. I was going to Europe and Paris, and I would just walk for hours, the 20,000 steps a day. Every single thing and nothing was working.”

Williams said that even when she lost weight, she craved calories because her “ body liked to be at a certain weight.”

“It’s so weird, because whenever I lose weight, all of a sudden I’ll get even hungrier,” she shared. “And when I reach a certain weight, it wants to go back the other way.

“That’s your biology,” Oprah responded

Williams recently showed her support for the GLP-1 medication and announced her partnership with telehealth company Ro. She noted that her body has been the subject of scrutiny since she was a teenager.